Endocrine Abstracts

Objective: A diabetic state is causally related to heart failure (HF) which is a leading cause of mortality. Early detection of high-risk individuals is imperative for primary prevention. The aim of this study was to investigate the role of N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) in patients with diabetes type 2 (DT2).Methods: We investigated 86 patients both sexes with DT2 aged 65.54±11.37 years (from 50 to 65 years) without clinical ...

Introduction: Many endocrinopathies such as acromegaly, Cushing’s syndrome (CS), pheomochromocytom and lipodystrophia can be associated with insülin resistance and unregulated diabetes mellitus (DM).Case report: A 37 –year- and 2 months pregnant women admitted to our out patient clinic for regulation of hyperglycemia. On physical examination; Blood Pressure: 140/95 mmHg, Body Mass Index: 31 kg/m2, central obesity, acanthosis nig...

Introduction: Early prediction of anticancer therapy cardiotoxicity is essential for applying proper preventive and supporting therapeutic strategies.Objective: To evaluate plasma N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) related to cardiac dysfunction assessed by transthoracic 2D echocardiography (2D-TTE) in patients with cancer and early onset asymptomatic anthracycline-induced cardiomyopathy (AIC).Methods:...

Instruction: Previous studies have been shown that obese individuals have reduced natriuretic peptide levels. But conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors. We investigated the relationship between plasma N-terminal pro-B-type natriuretic peptide levels (NT-proBNP) and metabolic syndrome (MetS), metabolic risk factors in 469 patients free of heartfailure.Material and methods: Two hundred and thir...

Introduction: Nitric oxide (NO) plays a wide spectrum of biological actions including a positive role in oocyte maturation and ovulation. Free radicals have been shown elevated in PCOS and therefore would be responsible for quenching NO that, in turn, would play a role in determining oligo or amenorrhea connoting PCOS. We recently demonstrated that the combined administration of N-acetylcysteine (NAC) and arginine (ARG) is able to exert an antioxidant action leading to ...

Aim: To assess concentration (conc) of arginine vasopressin (AVP) and conc of N- terminated naturetic propeptyde type B (NTpBNP) in patients (pts) after cardiac arrest (CA) and their role for clinical state of pts after CA.Material: 52 pts after CA, 36 men and 16 women, in the age 62±13 years. CA was caused by ventricular fibrillation in 31 cases, by asystolia in 15 and by pulseless electrical activity in 6. 28 pts died after CA (P-CA-D), 24 survive...

Objective: The cardiac hormone brain natriuretic peptide (BNP), including the N-terminal fragment of the prohormone (NT-proBNP) have in cross-sectional studies been demonstrated to be inversely associated with BMI. Clearance of these peptides by adipocyt specific receptors have been suggested. We therefore investigated the impact of weight loss on plasma levels of NT-proBNP and adiponectin in obese individuals.Methods: A total of 20 obese women and 2 men...

Combination chemotherapy for breast cancer offers the potential for improving drug efficacy through enhancement of cancer cell killing. Theoretically, the mechanistic basis underlying this approach may depend on multiple targets and/or amplification/interaction of putative proapoptotic signals. The synthetic retinoid N-(4-hydroxyphenyl) retinamide (4HPR) has proved effective as a chemopreventative and therapeutic agent in breast cancer, however, the mechanisms mediating this a...

Proadrenomedullin N-terminal 20 peptide (PAMP) and adrenomedullin are hypotensive peptides that are cleaved from the proadrenomedullin peptide. Adrenomedullin can act via the complex calcitonin receptor like receptor (CRLR) and receptor activity modifying protein (RAMP) 2 or the putative receptor, CRLR/RAMP3 complex. CGRP (Calcitonin gene related peptide) binding is conferred by the CRLR/RAMP1 complex. This study was carried out to see how adrenomedullin and PAMP affected the ...

The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR) has manifold actions which may be involved in its chemopreventive effects on breast cancer growth and progression. Ceramide is a sphingolipid involved in the mammalian stress response and is implicated in the induction of apoptosis. Its role in the mechanism of 4HPR action has not been fully explored. Here we attempt to elucidate the relationship between 4HPR, ceramide production and cell viability. Survival of viable...